Dehydroepiandrosterone (DHEA) is a hormone that your body naturally produces in the adrenal gland. DHEA assists generate other hormones, including testosterone and estrogen. Normal DHEA stages peak in early adulthood and then gradually tumble as you age.

A synthetic model of DHEA is obtainable as a pill, capsule, powder, topical product and gel.

Persons use DHEA as an anti-getting old treatment and to boost actual physical overall performance. DHEA is also employed to handle despair and indicators of menopause.


Study on DHEA for specific situations includes:

  • Growing older. In concept, having DHEA health supplements to manage DHEA stages could sluggish the getting old approach, probably improving very well-remaining, cognitive perform and body composition. But so much investigate hasn’t proved this to be true. Extra reports are needed to improved realize regardless of whether DHEA supplementation can counteract some of the outcomes of getting old. A modest study prompt that having DHEA health supplements could possibly boost pores and skin hydration and firmness, and reduce getting old spots in elderly grown ups.
  • Melancholy. DHEA could possibly be far more effective at dealing with despair than placebo, particularly in individuals with small DHEA stages.
  • Osteoporosis. Research conclusions on the outcomes of DHEA supplementation in the therapy of osteoporosis are mixed. Extra investigate is needed to figure out regardless of whether having DHEA health supplements enhances bone density in older grown ups with small DHEA.
  • Vaginal atrophy. Constrained investigate implies that DHEA could possibly boost vaginal dryness in postmenopausal girls.

Study on the outcomes of DHEA on muscle energy and actual physical overall performance experienced mixed final results, but most reports point out DHEA supplementation has no outcome on muscle energy in young or older grown ups. The Nationwide Collegiate Athletic Association has banned DHEA use among the athletes.

DHEA could possibly inevitably prove to have benefits in dealing with individuals diagnosed with specific situations, such as adrenal insufficiency and lupus. Having said that, even further reports are needed.

Reports have revealed high quality control of this complement to generally be small.

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While some investigate implies that DHEA could possibly be a little beneficial in dealing with despair and vaginal atrophy, there is minor proof to help anti-getting old statements. Also, DHEA use can cause critical side outcomes. Stay clear of applying this complement.

Safety and side outcomes

DHEA is a hormone. Use of this complement could possibly maximize stages of androgen and have a steroid outcome. DHEA also could possibly maximize the hazard of hormone-delicate cancers, including prostate, breast and ovarian cancers. If you have any kind of cancer or are at hazard of cancer, you should not use DHEA.

Never use DHEA if you’re expecting or breastfeeding.

Take into account preventing use of DHEA if you have higher cholesterol or a condition that impacts the supply of blood to the heart (ischemic heart sickness). DHEA could possibly lower higher-density lipoprotein (HDL), or “excellent,” cholesterol stages.

Use of DHEA also could possibly worsen psychiatric diseases and maximize the hazard of mania in individuals who have mood diseases.

DHEA also could possibly cause oily pores and skin, pimples and unwelcome, male-sample hair advancement in girls (hirsutism).


Doable interactions include things like:

  • Antipsychotics. Use of DHEA with antipsychotics such as clozapine (Clozaril, Versacloz, some others) could possibly lower the drug’s effectiveness.
  • Carbamazepine (Tegretol, Carbatrol, some others). Use of DHEA with this drug employed to handle seizures, nerve discomfort and bipolar condition could possibly lower the drug’s effectiveness.
  • Estrogen. Never use DHEA with estrogen. Combining DHEA and estrogen could possibly cause indicators of extra estrogen, such as nausea, headache and insomnia.
  • Lithium. Use of DHEA with lithium could possibly lower the drug’s effectiveness.
  • Selective serotonin reuptake inhibitors. Use of DHEA with this form of antidepressant could possibly cause manic indicators.
  • Testosterone. Never use DHEA with testosterone. Combining DHEA and testosterone could possibly cause indicators such as small sperm depend and enlarged breasts in guys (gynecomastia) and the enhancement of typically male traits in girls.
  • Triazolam (Halcion). Utilizing DHEA with this sedative could possibly maximize the outcomes of this drug, creating abnormal sedation and impacting your respiratory and heart rate.
  • Valproic acid. Use of DHEA with this medication employed to handle seizures and bipolar condition could possibly lower the drug’s effectiveness.