Overview

St. John’s wort (Hypericum perforatum) is a flowering shrub indigenous to Europe. It will get its identify from the reality that it often blooms on the birthday of the biblical John the Baptist.

The bouquets and leaves of St. John’s wort contain lively components this kind of as hyperforin. St. John’s wort is available as a complement in teas, tablets, liquids and topical preparations.

Folks use St. John’s wort to treat depression and menopausal symptoms.

Evidence

Investigate on St. John’s wort use for specific disorders exhibits:

  • Depression. Many studies assistance the therapeutic reward of St. John’s wort in managing mild to moderate depression. In reality, some study has revealed the complement to be as successful as various prescription antidepressants. It really is unclear whether or not it really is valuable in the treatment of extreme depression. Since St. John’s wort interacts with several remedies, it may not be an appropriate decision, especially if you get any prescription medicine.
  • Menopausal symptoms. Some evidence implies that having St. John’s wort by yourself or in mixture with black cohosh or other herbs may minimize menopausal symptoms this kind of as very hot flashes.
  • Somatic symptom ailment. Some studies suggest that St. John’s wort may be valuable for the treatment of this affliction that causes extreme anxiety about physical symptoms this kind of as suffering, weak spot or shortness of breath.

Our get

Yellow light: Caution

Caution

St. John’s wort can be successful for managing mild to moderate depression. Even so, the complement interacts with several remedies and can trigger really serious facet consequences. Consult with with your medical doctor prior to having St. John’s wort if you get any other remedies.

Protection and facet consequences

When taken orally for up to twelve weeks in appropriate doses, St. John’s wort is typically thought of risk-free. Even so, it may perhaps trigger:

  • Agitation and anxiety
  • Dizziness
  • Diarrhea, constipation and tummy pain
  • Dry mouth

Other facet consequences may perhaps include things like:

  • Exhaustion and sleeplessness
  • Headache
  • Greater sensitivity to sunlight (photosensitivity)

There is just not more than enough details about the protection of using St. John’s wort topically.

Don’t use St. John’s wort through pregnancy or although breastfeeding.

Interactions

The record down below contains some acknowledged interactions. Even so, other medicine may perhaps also interact with St. John’s wort. Test with your medical doctor prior to using St. John’s wort in mixture with any other medicine, particularly prescription remedies.

  • Alprazolam (Xanax). Having St. John’s wort with this drug used to alleviate symptoms of anxiety may lower the drug’s influence.
  • Antidepressants. Having St. John’s wort with antidepressants may enhance the chance of the accumulation of superior ranges of serotonin in your physique. As well a lot serotonin can trigger mild to extreme facet consequences. Having this complement and an antidepressant demands a doctor’s supervision.
  • Barbiturates. Having St. John’s wort with a drug that functions as a central anxious procedure depressant (barbiturate) may lower barbiturate-induced snooze time.
  • Bupropion (Wellbutrin SR, Forfivo XL). Having St. John’s wort with this antidepressant may lower the drug’s influence.
  • Sure chemotherapy medicine. Having St. John’s wort with irinotecan (Camptosar, Onivyde), docetaxel (Taxotere) or imatinib (Gleevec) may minimize the chemotherapy drug’s consequences.
  • Sure immunosuppressive medicine. Having St. John’s wort with tacrolimus (Prograf, Astagraf XL, others) or cyclosporine (Neoral, Sandimmune, others) may lower the drug’s influence.
  • Sure statins. Having St. John’s wort with simvastatin (Zocor, Flolipid) may minimize the drug’s usefulness.
  • Contraceptive medicine. Use of St. John’s wort with contraceptive medicine may consequence in breakthrough bleeding, irregular bleeding or unplanned pregnancy. An additional or substitute form of delivery regulate may be wanted.
  • Cytochrome P450 1A2 (CYP1A2), Cytochrome P450 2B6 (CYP2B6), Cytochrome P450 2C19 (CYP2C19) and cytochrome P450 2C9 (CYP2C9) and cytochrome P450 3A4 (CYP3A4) substrates. Don’t get St. John’s wort if you might be having a drug impacted by these enzymes.
  • Dextromethorphan. Having St. John’s wort with this cough suppressant may enhance the chance of the accumulation of superior ranges of serotonin in your physique.
  • Digoxin (Lanoxin). Having St. John’s wort with this coronary heart medication can minimize the drug’s influence.
  • Fexofenadine (Allegra Allergy). Having St. John’s wort with this antihistamine may trigger much too a lot of the drug to make up in your physique, worsening normal facet consequences.
  • Ketamine (Ketalar). Having St. John’s wort with ketamine may minimize the drug’s anesthetic influence.
  • Narcotics. Don’t get St. John’s wort with methadone (Methadose). Having St. John’s wort with sure narcotics may minimize the drug’s usefulness. Combining the complement with narcotics may also enhance narcotic-induced snooze time and painkilling consequences.
  • Non-nucleoside reverse transcriptase inhibitors. Having St. John’s wort with a person of these anti-HIV medicine could minimize the drug’s influence.
  • Omeprazole (Prilosec). Don’t get St. John’s wort with this drug used to treat persistent heartburn. The complement can minimize the drug’s usefulness.
  • Phenytoin (Dilantin, Phenytek). Having St. John’s wort with this anticonvulsant may consequence in reduction of seizure regulate.
  • Photosensitizing medicine. Having St. John’s wort with a drug that raises sensitivity to sunlight may enhance the chance of a reaction.
  • Protease inhibitors. Having St. John’s wort with this form of antiviral drug can minimize the drug’s usefulness.
  • Triptans. Don’t get St. John’s wort with these remedies used to treat migraines. The complement may enhance the chance of the accumulation of superior ranges of serotonin in your physique. As well a lot serotonin can trigger mild to extreme facet consequences.
  • Voriconazole. Having St. John’s wort with this antifungal drug may minimize the drug’s usefulness.
  • Warfarin (Jantoven). Having St. John’s wort with this drug taken to minimize blood clotting may lower the drug’s influence.